This is the 8th event organised by SCI’s Young Chemists’ Panel to highlight the challenges associated with ADMET (Adsorption, Distribution, Metabolism, Elimination and Toxicity) in Medicinal Chemistry. The aim is to provide participants with a practical understanding of ADMET parameters, how to diagnose common ADMET problems and how to improve compound design to overcome these problems.
The event is aimed at organic chemists (graduate or PhD) working in a pharmaceutical research environment and students thinking about a career in this sector. Participants are provided with a booklet containing the material presented, worked examples and literature references.
James Smith, Astrazeneca
Kurt Pike, Johnson & Johnson
Ted Parton, MeKinOpsis
Simon Peace, GSK
For further information and prices, please email firstname.lastname@example.org
Thursday 23 February 2023
- Registration and refreshments
- Introduction and welcome to Day 1
Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem – Solubility, Permeability, PGP Efflux • Chemical strategies to improve absorption • Worked examples
- Refreshment break
- Metabolism and clearance I
Practical understanding of concepts & parameters • How do you know you have a problem? • Sources of problem – Phase I / Phase II Metabolism • Chemical strategies to address metabolism • Worked examples
- Metabolism and clearance II
Cytochrome P450s and Drug-Drug interactions • Volume of distribution – how to understand and influence • Plasma protein binding – impact & influence • Worked examples
- Refreshment break
- Drug toxicity and toxicology
Context & common issues • Design strategies to mitigate risks of hERG, phospholipidosis, reactive metabolites & genotoxicity
- Summary and closing remarks
- Networking reception and close
Friday 24 February 2023
Day 2 of the ADMET event is an interactive industry-standard DMPK workshop developed and facilitated by professional drug-discovery scientists to provide a step-change in knowledge and understanding. The objective is to embed key principles from day 1 in the context of free (unbound) drug and increase fluency in handling & interpreting DMPK data. The workshop comprises training in small groups, with expert scientists from ADMET and medicinal chemistry on hand to ensure a rich training experience.
- Introduction & Welcome to Day 2
- Interactive workshop in breakout groups
- Worked examples in breakout groups
- De-brief & wrap-up
SCI’s Young Chemists’ Panel are committed to promoting diversity and equality in the chemical sciences. We aim to identify high quality speakers for all our conferences with inclusivity of gender and ethnicity. Attendees from all backgrounds and ages are welcome.
Venue and Contact
|Before early bird - ends 12 Jan 2023
SCI Member - £200
Non-member - £300
Student Member - £85
|After early bird
SCI Member - £250
Non-member - £350
Student Member - £105
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Booking terms and conditions
SCI Members attending this meeting are able to claim CPD points.
Ross Mclennan, University of Dundee
Kim Roper, University of Birmingham
Russell Wood, Malvern Panalytical