15 March 2013

Exploiting the Biology of Microbial Toxins for the Non-parenteral Delivery of Biopharmaceuticals

Organised by:

SCI's Biotechnology Group in conjunction with the University of Westminster

University of Westminster, London

Registration Closed

This event is no longer available for registration.


Non-parental delivery of biopharmaceuticals is highly attractive not only for its improved convenience and potential to localise the delivery to some agents to the lung or gut where they are administered. Oral delivery has been suggested to have additional advantages relative to subcutaneous (SC) injection: a greater safety-to-efficacy ratio for molecules with targets in the liver and the potential for reduced immunogenicity.

Additional potential benefits for oral bio-therapeutic delivery involve general health and safety as well as environmental concerns. Studies have examined a strategy of emulating certain bacterial toxins to identify a potential approach to achieve the goal of non-parenteral delivery of biopharmaceuticals. Specifically, in examination of mechanisms(s) used by exotoxin A from Pseudomonas aerugionsa (PE) to efficiently transport its toxic cargo through polarized epithelial cell without intoxicating them. Once across an epithelial barrier, PE targets cells enriched in surface-expressed CD91, a large scavenger (low density lipoprotein-like receptor) protein.

The modular nature o PE allows it to be easily manipulated be genetic engineering: a non-toxic form of PE can be used to deliver antigenic structures to professional antigen presenting cells following mucosal application and use of just the transcelluar transport elements can allow for the systematic delivery of protein therapeutics. Thus, the remarkable nature of microbial toxins rapidly enter and transport across polarized epithelial cells can be exploited for a variety of applications that might provide pharmaceutical benefit.

Venue and Contact

University of Westminster

University of Westminster, School of Life Sciences, 115 New Cavendish Street London W1W 6UW

For a Map click here

SCI Comms Team

+44 (0)20 7598 1561

Email: Communications@soci.org

This is a free event, no need to book.

Become an SCI Member and save on this and future events

See Membership Options

Sign up as an Event Member to join this event. SCI Full or Student Members receive discounts on event registrations

Booking Process/Deadlines

Booking terms and conditions

CPD Info

SCI Members attending this meeting are able to claim CPD points.

CPD logo 2021-2023

Additional Info


Professor Randal Mrsny
Deparment of Pharamacy and Pharmacology, University of Bath