15 May 2013

Choosing the Right Target in Drug Discovery

Organised by:

SCI’s Fine Chemicals Group

SCI HQ, London, UK

Registration Closed

This event is no longer available for registration.

This symposium will cover the current approaches to novel target selection in drug discovery. The differentiation of drug candidates through on- and off-target mechanisms and pathways will be discussed. Methods for target validation, mechanism clarification, measuring or predicting tractability, efficacy and safety will be covered to show how a better understanding of these interacting effects can allow the development of better quality Lead and Clinical Candidates.
This event is aimed at all scientists interested in furthering their knowledge of drug discovery. It will also have wide appeal to members of the drug discovery community eager to understand how to select and validate novel targets. Analysis of pathway effects with on- and off-target activity of drug candidates can help in compound prioritisation and optimisation. 

Event Day

Event Schedule
Registration and refreshments
Welcome and intro
Targeting multi-protein regulatory systems: Allostery and protein-protein interactions.
Phenotypic vs target screening approaches – black or white or shades of grey Graeme Walker, AstraZeneca
Selection and validation of cancer drug targets: Objective computational assessment and chemical tools Paul Workman,The Institute of Cancer Research, London
Lunch and exhibition
The genomics of drug sensitivity in cancer: preclinical biomarker discovery in cancer cells Mathew Garnett, Sanger Institute
RNAi screening: pitfalls and bear-traps Michael Howell, London Research Institute, CRUK
Mode of action analysis and biomarker discovery by phospho-proteomics Christian Eckert, Evotec, Germany
Refreshment break
Drug Discovery Toxicology: approaches to improving candidate drug safety Peter Newham, AstraZeneca
The expanding role of the medicinal chemist: application of chemical tools to enhance biological target selection Ian Storer, Pfizer Neusentis
Closing remarks and Wine reception (Evotec)

Venue and Contact


SCI HQ, London, UK

Conference Team

Tel: +44 (0)20 7598 1561

Email: conferences@soci.org


Earlybird fees - before 3 April 2013
GB£100 . . . . . . . . .SCI Member 
GB£30. . . . . . . . . . SCI Student
GB£60. . . . . . . . . . SCI Subsidised Member
GB£130 . . . . . . . . .Non Member

Standard fees - after 3 April 2013
GB£120 . . . . . . . . .SCI Member 
GB£36 .. . . . . . . . . SCI Student
GB£72 . . . . . . . . . .SCI Subsidised Member
GB£156 . . . . . . . . .Non Member

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Booking Process/Deadlines

Booking terms and conditions

CPD Info

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Additional Info
Exhibition and Sponsorship

An exhibition will take place alongside the conference for companies and related organisations who may wish to exhibit. Please email conferences@soci.org for further information and prices. Spaces are limited and will be allocated on a first-come, first-served basis.