8 September - 11 September 2013

17th RSC / SCI Medicinal Chemistry Symposium

Organised by:

RSC's Biological and Medicinal Chemistry Sector and SCI's Fine Chemicals Group

Diss

Registration Closed

This event is no longer available for registration.

Synopsis

The Medicinal Chemistry Symposium 2013: the organisers invite you to the 17th RSC-SCI Medicinal Chemistry Symposium, Europe's premier biennial Medicinal Chemistry event, focusing on first disclosures and new strategies in medicinal chemistry. Reflecting current trends in medicinal chemistry and pharmaceutical research, the theme of the conference will be 'Improving Success?' The scientific programme will feature lectures and short talks across the full range of drug targets including enzyme inhibitors, ligands for receptors and ion channels as well as talks on key enabling processes and technologies. There will also be poster sessions with a proportion of posters selected for flash presentations.

Attendees

This conference will be of interest to both academic and industrial scientists engaged in all aspects of the drug discovery and development process. It aims to showcase first disclosures of significant new therapeutic agents across all disease areas, and provide a forum for discussion of current topics and thinking at the forefront of medicinal chemistry.

Programme

14th September

Event Section

09:00: Potent, selective and orally efficacious inhibitors of Plasmodium falciparum Protein Kinase G (PfPKG): targeting new malaria treatments Jonathan Large, MRC Technology, UK
09:45: The design and optimisation of selective Protein Kinase C theta (PKCθ) inhibitors for the treatment of autoimmune diseases Juan-Miguel Jimenez, Vertex Pharmaceuticals (Europe) Ltd, UK
10:30: Refreshments
11:00: Analogues of fenarimol as potential new treatments for Chagas Disease Martine Keenan, Epichem, Australia
11:45: Cell-penetrating Zwitterions: a case study of carnitine palmitoyl transferase inhibitors Simona Ceccarelli, Roche, USA
12:15: Rational design of covalent enzyme inhibitors Adam Gilbert, Pfizer, USA
12:45: Lunch (in dining hall, coffee after lunch in marquee)
14:00: CRTh2: Can Residence Time help? Rick Roberts, Almirall, Spain
14:45: From screening impurity to potent and selective ROMK inhibitors - the path to new mechanism diuretics Alex Pasternak, Merck & Co Inc, USA
15:30: Improving success in the development of novel PET ligands for CNS indications Elizabeth Beck, Pfizer, USA
16:00: Closing Remarks

8th September

Event Section

1500: Registration and Refreshments
18:30: Barbecue

9th September

Event Section

08:55: Welcome and opening remarks Steve Swallow, Chair, Organising Committee, AstraZeneca, UK
09:00: GLPG0974, a FFA2 antagonist from hit to clinic Laurent Saniere, Galapagos, France
09:45: CCR2 antagonists for the treatment of neuropathic pain - the discovery and development of AZD2423 John Cumming, AstraZeneca, UK
10:30: Refreshments in marquee
11:00: Identification of orexin antagonists for the treatment of insomnia and addiction using structure-based drug design Miles Congreve, Heptares, UK
11:45: A multivalent approach to peripherally restricted m-opioid receptor antagonists(PμMA) for Opioid-induced Bowel Dysfunction (OBD) Daniel Long, Theravance Inc, USA
12:30: Poster flash presentations
12:45: Lunch (in dining hall, coffee after lunch in marquee)
14:00: Enhancing molecule quality by combining fragment approaches with early pharmacy input - an example with PGD2 Synthase Simon Hodgson, Hodgson Pharma Consulting / GlaxoSmithKline, UK
14:45: TBC John Link, Gilead, USA
15:30: Refreshments
16:00: Non-ATP-site-directed kinase inhibitors: the IGF1R case Frederic Berst, Novartis Institutes for Biomedical Research, Switzerland
16:45: The discovery and profile of narrow spectrum kinase inhibitors as novel treatments for inflammatory pulmonary disease Stuart Onions, Sygnature Discovery, UK
17:30: Poster flash presentations
17:45: Poster Session 1 and wine reception
19:00: College Dinner with bar open untill 24:00

Tuesday 10th

Event Section

09:00: Discovery of novel agonists of GPR119 for the treatment of Type II Diabetes Jamie Scott, AstraZeneca, UK
09:45: TRPM8 blockade and its role in cold pain signalling Robert Owen, Pfizer, UK
10:30: Refreshments
11:00: Development of SGI-110, a potent hypomethylating agent, as epigenetic therapy in cancer Sanjeev Redkar, Astex Pharmaceuticals, USA
11:45: New approaches to traditional anti-mitotic chemotherapy: structure based drug design of the Eg 5 inhibitor NVP-BQS481, from computer to clinic Paul Barsanti, Novartis Institutes for Biomedical Research, USA
12:30: Malcolm Campbell Award
12:45: Lunch (in dining hall, coffee after lunch in marquee)
14:00: A novel approach to asthma therapy: inhibitors of the allergenic house dust mite peptidases Trevor Perrior, Domainex Inc, UK
14:45: Discovery of 11β-HSD1 inhibitors for the treatment of Alzheimer's dementia Arnab Chatterjee, Genomics Institute of the Novartis Research Foundation, USA
15:30: Refreshments
16:00: Molecule properties and compound developability - what's new? Tim Ritchie, TJR Chem, Italy
16:30: Medicinal chemistry experts in pharma are helping us to generate freely available probes for target discovery Chas Bountra, University of Oxford and SGC, UK
17:15: Poster flash presentations
17:30: Poster session 2 and refreshments
19:00: Walk to St John's
20:00: Gala dinner at St John's

Venue and Contact

Churchill College

Maggi Churchouse
3 East Barn
Market Weston Road
Thelnetham
Diss
IP22 1JJ
UK

Maggi Churchouse

Tel: +44 (0)1359 221004

Email: maggi@maggichurchouseevents.co.uk

Fees

Dinners

The barbecue (Sunday), dinner (Monday), and Gala dinner (Tuesday) are all included in the registration fee for those who are resident at Churchill College. Non-resident delegates may book all of these dinners when registering.
The Gala dinner will be held in the magnificent 16th Century Hall at St John's College, a short walk from Churchill. Pre-dinner drinks will be held either on the Backs Lawn or in the Cloisters, before walking over the Bridge of Sighs to the impressive dining hall.

GB£30.00 . . . . . . . . Barbeque on Sunday 8th
GB£40.00 . . . . . . . ..College Dinner on Monday 9th
GB£60.00 . . . . . . . ..Gala Dinner on Tuesday 10th

Accommodation Package

Accommodation for delegates at Churchill College comprises either a single study en-suite or a single study standard bedroom. Rooms will be allocated on a first-come, first served basis.
The Accommodation Package is for three nights' accommodation, Sunday to Tuesday, 8th to 10th September inclusive. This includes full breakfast Monday to Wednesday, the barbecue on Sunday evening, an evening meal on Monday and the Gala dinner at St John's on Tuesday. Rooms must be vacated by 10 am on the day of departure. Luggage storage will be available. For those not wishing to stay at Churchill, we have also held rooms at nearby Murray Edwards College and the Hotel Felix (see website), Bedrooms will be available from 2 pm on the day of arrival, and delegates may make alternative direct bookings via may make alternative direct bookings via www.visitcambridge.org

GB£440.00 . . . . . . . . Single Ensuite Room (with private bathroom)
GB£400.00 . . . . . . . ..Single Standard Room (with shared bathroom)

Delegate fees until 30 Apri
GB£370.00 . . . . . . . . SCI/RSC Member
GB£135.00 . . . . . . . ..Student Member
GB£460.00 . . . . . . . . Non Member

Delegate fees 1 May - 11 August
GB£440.00 . . . . . . . . SCI/RSC Member
GB£230.00 . . . . . . . ..Student Member
GB£548.00 . . . . . . . . Non Member

Delegate fees 12 August onwards
GB£490.00 . . . . . . . . SCI/RSC Member
GB£280.00 . . . . . . . ..Student Member
GB£598.00 . . . . . . . . Non Member

Students and bursaries

Discounted rates are available to RSC and SCI student members, and some student bursaries are available. Applications are invited from PhD and post-doctoral students studying at European academic institutions, preferably members of the RSC, SCI or EFMC. Those submitting abstracts for poster presentation will be favoured. To apply for a student bursary, please complete and return the bursary application form by 17th July.

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Booking Process/Deadlines

Booking terms and conditions

CPD Info

SCI Members attending this meeting are able to claim CPD points.

Additional Info

Organising Commitee

Mark Healy Novartis
Simon Peace GlaxoSmithKline
Gordon Saxty Astex Pharmaceuticals
Chris Swain Consultant
Nigel Swain Pfizer
Steve Swallow (Chairman) AstraZeneca
Andrew Williams Lilly

Call for Poster Papers

The poster session is an important part of the meeting and contributions from the whole field of medicinal chemistry are invited: a number of flash presentation sessions are planned which will involve two-minute presentation of poster highlights. To submit a poster abstract, please download a template from the website, and submit your abstract to the Secretariat by 17th July or earlier. Please indicate if you would not like to be included for consideration in the flash presentation session, and the organising committee will decide on these speaker slots after 17th July.

Sponsorship & Exhibition

The exhibition will run alongside the conference during refreshment breaks and poster sessions. Those who wish to exhibit should book early to avoid disappointment. Exhibition stands may be booked online or via the registration form, and the rate includes two stand staff and daytime refreshments. Please contact the secretariat for sponsorship opportunities.

Social Events

Non residents can book for the social events online

Venue and travel

Churchill College is one of 31 Colleges that comprise the University of Cambridge. Founded in 1960, it is a 15 minute walk from the centre of Cambridge. Despite the concentration of hi-tech and science industries around Cambridge, the centre still retains the atmosphere of a small town, renowned for the many university colleges and places of interest. Further information about Cambridge and alternative accommodation can be found at: www.visitcambridge.org.

Travel to Cambridge is convenient by road or rail. Churchill College is on Storey's Way, off the A1303, one mile west of the city centre and close to the M11 motorway. There are frequent train services to Cambridge from London King's Cross and Liverpool Street stations. The nearest international airport is London Stansted (30 miles) which has rail and coach links to Cambridge. From London Heathrow and Gatwick airports, there are express rail links to central London for onward rail journeys as above. There are also coach links from both airports to Cambridge (one change).